Ottaviano Fregoso di Agostino (1470-1524).
Ottaviano is considered as the person with the most natural qualities of the Fregoso family. He was born in Genoa from Doge Fregoso and Gentile da Montefeltro, daughter of the Duke of Urbino. He spent most of his youth at the court of Urbino, where he received a refined literary education such as that he will be praised by Pietro Bembo and by Francesco Guicciardini. In 1497, with the help of Charles the VIII's troops he tried to expel the Sforzas from Genoa. In 1502 he participated at the Diet of La Magione as envoy of the Duke of Urbino. After the death of Alexander VI, the new Pope Julius II, who had very high admiration for Ottaviano, bestowed on him the title of General of the Holy Church, and in 1506 he was sent to Bologna to rescue the city which was under the power of Giovanni Bentivoglio. In the same year he participated with his cousin Giano II in an action directed to expel the French from Genoa. He was proclaimed Doge of Genoa in June 1513. The ascent of Frederick I to the throne of France was fateful to his government which fell in 1515. When Genoa was conquered by Spanish and Swiss forces in 1522, Ottaviano , who was suffering from gout, was captured and imprisoned in a small jail on the island of Ischia where he died in 1524.

In the fourth book of Baldassarre Castiglione's The Courtier, Ottaviano Fregoso is deputized to expound on the qualities that add to Courtier's perfection, and considers the Courtier's relations with the Prince, urging the duties of employing his qualities and accomplishment so that the prince may be lead to seek good and shun evil.